Get the facts, learn how to check for fleas and find the best treatment options for your dog. 44 8 Comments Share The indoxacarb in Activyl is bioactivated in the flea by enzymatic N-decarbomethoxylation changing it to a more active, highly insecticidal metabolite.1. 6.Activyl vs. Revolution Comparison | PetMeds, 7.Activyl for Cats over 4kg Dark Blue 6s **DISCONTINUED, 8.The 5 best flea treatments for cats, with advice from veterinarians, 9.Is Activyl for Cats Discontinued? It is effective at killing adult and developing stages of fleas and there is no known resistance. The first flea control product to use this new targeting through bioactivation technology. There will always be a demand for products that keep our beloved pets safe and healthy. chevron_right. Alternative metabolic pathways (indanone and oxadiazine ring cleavage) in mammals convert indoxacarb mainly to non-toxic metabolites. Activyl is indicated for the treatment of fleas (Ctenocephalides sp.) Your email address will not be published. Dong K. Insect sodium channels and insecticide resistance. The manufacture and use of the product released a number of harmful chemicals into the environment, and with it gone, there will be one less source of pollution. So they need their own, tailored plan for overcoming their emotional reactions. That means it is only applied to a small area of skin but soon spreads on the skin and coat. Indoxacarb is a pro-insecticidal compound that requires enzymatic activation in the flea where it is converted into its highly potent insecticidal form. Copyright 1995-2023 Merck & Co., Inc., Rahway, NJ, USA and its affiliates. 1,2 Flea & Ticks Resources Keep Fleas & Ticks Off Your Dog FLEAS Fleas are tiny pests that can create big problems for your pet. Cats that have been on Activyl for an extended period of time may be at risk for reinfestation if they are no longer treated. You can refer to the answers. After that, the fleas will become resistant to the spray and a repeat application may be necessary. - Cats and kittens from 8 weeks of age. Activyl stops fleas from feeding, kills all flea stages (egg, larvae and adult), and inhibits flea development in the environment.. Activyl contains indoxacarb, which was specifically developed to overcome insect resistance in crop protection. Some are also approved for treatment and control of ear mite infestations and some gastrointestinal parasite infections, and a few are also approved for prevention of heartworm disease. Activyl stops fleas from feeding, kills all flea stages (egg, larvae and adult), and inhibits flea development in the environment.. This decision was made as part of the regular business practice of continuously evaluating the Merck Animal Health portfolio and allocating resources to those products that best fit the company's long-term strategic objectives. 2007;7:1730. See below for suggested alternatives. Ticks can be found right in your own backyard. ACTIVYL for Dogs and Puppies prevents and protects against infestation of fleas for 1 month. The flea problem is likely to get worse before it gets better, as feral and indoor/outdoor cats that are not treated for fleas will continue to reproduce and spread the pests. The active ingredient in the product, imidacloprid, worked by killing fleas on contact. Manage Settings Activyl Tick Plus must not be used in cats as adverse reactions and even death can occur. Isoxazoline products have been associated with neurologic adverse reactions, including muscle tremors, ataxia, and seizures in some dogs and cats; Although most dogs and cats havent had neurologic adverse reactions, seizures may occur in animals without a prior history; Many products are available for prevention and control of flea and tick infestations. Cytopoint was marketed as a wonder drug for allergies in pets, especially dogs. When tested for a 2-month application period, *BRAVECTO kills fleas and prevents flea infestations for. Purchasing Bioactivation should be a consideration if this is something you want to consider. Kills fleas, & Flea Eggs up to three months and ticks for one month. This leaves cat owners in a difficult position, as they must decide whether to risk using an ineffective product or to go without flea protection altogether. When used as directed, Activyl for cats was highly effective at preventing and treating flea infestations. It is approved for use on cats and kittens over 2 lb from 8 weeks of age. First, without an effective treatment like Activyl, flea infestations in cats will become more common. An example of data being processed may be a unique identifier stored in a cookie. I have a 13-week-old puppy, and I used Activyl on him for fleas. info About GoodRx Prices. Until your communication, I was not aware that indoxacarb the highly toxic, hazardous insecticide in Activyl was approved for companion animal use. Drug Info. In the recent past, the pesticide has been disappearing on the shelves and people have been wondering if its production has been discontinued. Some of these alternatives include: BRAVECTO Topical Solution for Cats provides 12 weeks of protection against fleas and ticks in a single, easy-to-apply dose. [Answer + Alternatives] Petnile, 10.ACTIVYL Flea Treatment for Cats, over 9 lbs, 3 Doses (3-mos. If activyl is discontinued without a suitable replacement, these consequences can lead to serious health problems for your cat. However, as an allergy drug, there are numerous complaints about it that can easily make people think they would affect its production. Once inside the body, Activyl works by bioactivation, a mode of action that changes the chemical into a highly insecticidal substance. This will put a strain on shelters and rescue groups, and could result in more cats being euthanized. This is because the medication is often used to treat cats that are already dealing with the stress of living in a home with other animals or humans. Activyl Tick Plus for Dogs uses trusted and proven flea and tick control for double killing power. In warmer climates, fleas are present all year round, while in more temperate climates, fleas are present mainly from late spring through to late fall and even longer . A recent study by Merck Animal Health compared the efficacy of two products. Descriptions: Yes, Activyl for cats and dogs has been discontinued by the manufacturer. Activyl Protector Band [product label], Madison, NJ: Merck Animal Health. Unlike insects, mammals mostly metabolize indoxacarb into nontoxic metabolites. While Activyl is very safe and effective for most pets, I have seen occasional rare reactions in sensitive pets . While discontinuing use of Activyl may have some consequences, it is important to remember that these are typically minor and can be easily managed with proper medical care. - cgaa.org, Is Comfortis for Cats Discontinued? There are safer alternatives to repelling fleas, ticks and other biting insects. Learn More: What to do if my cat has a cold? There is no known flea resistance to indoxacarb. Hypothyroidism. Reactive behavior is a negative response to something that causes fear, anxiety, or stress in our dogs. Cats that are used to receiving regular doses of activyl may experience a sudden change in their energy levels and behavior. If youre thinking about using a flea shampoo or something similar, talk to your veterinarian first. Activyl ships by ground only due to Department of Transportation . What is the safest most effective flea treatment for Dogs? Yes, the active ingredients in Activyl are both safe and effective for cats. Free US Shipping! Zhao X, Ikeda T, Yeh JZ, Narahashi Y. Neurotoxicology 2003;24:8396. It's safe for use in dogs and puppies 14 weeks of age and older, and cats and kittens 16 weeks of age and older. [Reviews + Alternatives]. Differential sensitivity of sodium ion channels between insects and mammals: significantly lower concentrations are effective in insects. [Find Alternatives], Is Cytopoint for Dogs Discontinued? This could lead to a decrease in sales for the pet industry as a whole. For dogs: The most common adverse reaction reported is vomiting. What flea medicine is better than frontline? It's fragrance free. Some are applied topically, while others are given orally. If you have a reactive young dog do not assume that he will eventually grow out of his reactivity. Acepromazine. We'll contact your Vet to verify. Some of these products are used monthly, while others are used less often. The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network. Fleas can spread disease to wild animals, and their increased population will likely lead to more animals being affected. Activyl is a new flea control product that is highly selective for Fleas. Activyl Spot-On for Dogs and Puppies (over 4 lb and up to 14 lb), Activyl Spot-On for Dogs and Puppies (over 14 lb and up to 22 lb), Activyl Spot-On for Dogs and Puppies (over 22 lb and up to 44 lb), Activyl Spot-On for Dogs and Puppies (over 44 lb and up to 88 lb), Activyl Spot-On for Dogs and Puppies (over 88 lb and up to 132 lb). Starts at. Activyl is unique because indoxacarb was designed as a pro-insecticidethat requires biological or metabolic activation, also known as bioactivation, in susceptible insects to convert it to its highly insecticidal formthus enhancing its selective toxicity.1In addition, indoxacarb works at a site of action in the flea different from other commercialized insecticides used for flea control. There are a few other products on the market that are similar to Activyl, but they are not as effective and may be more expensive. How often should you change cat litter for two cats? Helpful Report abuse Phyllis Richter Put it on 8 dogs all did fine got rid of fleas It is easy to apply and provides One Frontline alternative is to switch to another topical product. Activyl breaks down rapidly in the environment and does not accumulate in plants or animals. There is no known flea resistance to indoxacarb. But when it comes to severe infestations and broad-spectrum protection, FRONTLINE is a better choice between the two. What is the safest and most effective flea and tick treatment for Dogs? In some cases, cats may become lethargic and stop using the litter box. Hypothyroidism occurs when the thyroid glands become underactive and don't produce enough of the hormones typical of the thyroid. However, it's important to remember that the pet industry is a very resilient business. Reactivity is rooted in feeling of fear and discomfort. If you suspect it is not controlling your pets fleas, you may, in certain cases, be able to reapply it in as little as two weeks and try again. $12.50. The manufacturer, Merck, has not stated the reason why they discontinued this . Ultimately, BIVI made the decision to discontinue the product in the interest of public safety. Most likely you made the purchase in a local store, which should be prohibited in every community and state. What is the best flea and tick medicine for dogs 2022? Speak to your veterinarian about this first if your flea medicine is not working. It treats fleas in all stages (adults, eggs, and larvae), as well as flea allergy dermatitis and lice. What is the number 1 flea treatment for dogs? If your dog or cat experiences any adverse event while using an isoxazoline product, first consult your veterinarian. In some cases, cats may become lethargic and stop using the litter box. In a nutshell, Cytopoint is not carcinogenic and therefore does not cause cancer. To view the purposes they believe they have legitimate interest for, or to object to this data processing use the vendor list link below. To report suspected adverse drug events for these products and/or obtain a copy of the Safety Data Sheet (SDS) or for technical assistance, contact the appropriate manufacturers at the following phone numbers: Merck Animal Health (Bravecto): 800-224-5318, Elanco Animal Health (Credelio): 888-545-5973, Boehringer Ingelheim (Nexgard): 888-637-4251, Zoetis (Simparica, Revolution Plus): 888-963-8471, If you prefer to report directly to the FDA, or want additional information about adverse drug experience reporting for animal drugs, see, Pet owners and veterinarians who have additional questions can contact.